Scalp follicle penetration
The role of the microbiome in scalp hair follicle biology and disease
Hair cycle-dependent changes in skin immune functions: anagen-associated depression of sensitization for contact hypersensitivity in mice. Caffeine was observed in blood samples at early times in normal skin but only after 20 min when the follicles were blocked.
Influence of the Vehicle on the Penetration of Particles into Hair Follicles
Transfollicular drug delivery: current perspectives
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Description: Whereas transfollicular penetration for particulate substances is not realistic due to their size, for smaller molecules, such as caffeine, the hair follicle can be regarded as a transport route into the living tissue. A major limitation in the studies reported to date is that they have either involved animal skin or excised human skin.